Leukemia-inhibitory factor-neuroimmune modulator of endocrine function.

  title={Leukemia-inhibitory factor-neuroimmune modulator of endocrine function.},
  author={Christoph Josef Auernhammer and Shlomo Melmed},
  journal={Endocrine reviews},
  volume={21 3},
Leukemia-inhibitory factor (LIF) is a pleiotropic cytokine expressed by multiple tissue types. The LIF receptor shares a common gp130 receptor subunit with the IL-6 cytokine superfamily. LIF signaling is mediated mainly by JAK-STAT (janus-kinase-signal transducer and activator of transcription) pathways and is abrogated by the SOCS (suppressor-of cytokine signaling) and PIAS (protein inhibitors of activated STAT) proteins. In addition to classic hematopoietic and neuronal actions, LIF plays a… CONTINUE READING