Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women.

Abstract

The placenta may play a critical role in inhibiting vertical transmission of HIV-1. Here we demonstrate that leukemia inhibitory factor (LIF) is a potent endogenous HIV-1-suppressive factor produced locally in placentae. In vitro, LIF exerted a potent, gp130-LIFRbeta-dependent, HIV coreceptor-independent inhibition of HIV-1 replication with IC50 values between 0.1 pg/ml and 0.7 pg/ml, depending on the HIV-1 isolate. LIF also inhibited HIV-1 in placenta and thymus tissues grown in ex vivo organ culture. The level of LIF mRNA and the incidence of LIF protein-expressing cells were significantly greater in placentae from HIV-1-infected women who did not transmit HIV-1 to their fetuses compared with women who transmitted the infection, but they were not significantly different from placentae of uninfected mothers. These findings demonstrate a novel pathway for endogenous HIV suppression that may prove to be an effective immune therapy for HIV infection.

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@article{Patterson2001LeukemiaIF, title={Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women.}, author={Bruce K. Patterson and Homira Behbahani and William J Kabat and Yvonne Sullivan and Maurice R G O'gorman and Alan L. Landay and Zareefa Flener and Naeem Khan and Ram Yogev and Johan P. A. Andersson}, journal={The Journal of clinical investigation}, year={2001}, volume={107 3}, pages={287-94} }