Leukemia inhibitory factor induces cumulus expansion in immature human and mouse oocytes and improves mouse two-cell rate and delivery rates when it is present during mouse in vitro oocyte maturation.

@article{Matos2008LeukemiaIF,
  title={Leukemia inhibitory factor induces cumulus expansion in immature human and mouse oocytes and improves mouse two-cell rate and delivery rates when it is present during mouse in vitro oocyte maturation.},
  author={Daniel G de Matos and Kathleen P Miller and Richard E Scott and Cam Anh Tran and D. Kagan and Selva G Nataraja and Ann E. Clark and Stephen L. Palmer},
  journal={Fertility and sterility},
  year={2008},
  volume={90 6},
  pages={
          2367-75
        }
}
OBJECTIVE To examine the role of leukemia inhibitory factor (LIF) during in vitro maturation (IVM) on human and mice cumulus expansion and mice oocyte competence by in vitro fertilization (IVF), culture, and embryo transfer (ET). DESIGN Prospective animal and human study. SETTING Serono laboratories and IVF clinic. PATIENT(S) Healthy women volunteers and 8-week-old female mice. INTERVENTION(S) Cumulus compacted human and mice oocytes were matured in IVM media with and without… CONTINUE READING
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