Leukemia inhibitory factor determines the growth status of injured adult sensory neurons.

@article{Cafferty2001LeukemiaIF,
  title={Leukemia inhibitory factor determines the growth status of injured adult sensory neurons.},
  author={William B J Cafferty and Natalie J Gardiner and Isabella Gavazzi and Jason A. Powell and Stephen B. McMahon and John K. Heath and Jeff Munson and James R. Cohen and Stephen W.N. Thompson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 18},
  pages={7161-70}
}
Conditioning injury to adult mammalian sensory neurons enhances their regeneration potential. Here we show that leukemia inhibitory factor (LIF) is a fundamental component of the conditioning response. Conditioning injury in vivo significantly increases the intrinsic growth capacity of sensory neurons in vitro from LIF+/+ mice. This conditioning effect is significantly blunted in sensory neurons from LIF-/- mice. Enhanced growth is rescued in vitro in LIF-/- mice by the addition of exogenous… CONTINUE READING
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