Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation.

@article{Graham2005LeukemiaIF,
  title={Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation.},
  author={Dianca R Graham and Paul Overbeek and John D Ash},
  journal={Investigative ophthalmology & visual science},
  year={2005},
  volume={46 7},
  pages={2601-10}
}
PURPOSE Activating ligands of gp130, including leukemia inhibitory factor (LIF), can block differentiation and function of retinal neurons. This study focused on determining whether LIF inhibits differentiation of photoreceptors by altering cell fate or by blocking the expression of essential transcription factors in vivo. METHODS Transgenic mice were generated that had lens-specific expression of the secreted human LIF protein. Retinal differentiation was assessed by histology and by gene… CONTINUE READING

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Nrl is required for rod photoreceptor development

Nature Genetics • 2001
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