Leukemia inhibitory factor and ciliary neurotropic factor promote the survival of Sertoli cells and gonocytes in coculture system.

@article{Miguel1996LeukemiaIF,
  title={Leukemia inhibitory factor and ciliary neurotropic factor promote the survival of Sertoli cells and gonocytes in coculture system.},
  author={M P De Miguel and Mieke de Boer-Brouwer and Ricardo Alfaro Paniagua and Robert van den Hurk and Dirk G de Rooij and Federica M F van Dissel-Emiliani},
  journal={Endocrinology},
  year={1996},
  volume={137 5},
  pages={1885-93}
}
Leukemia inhibitory factor (LIF) and ciliary neurotropic factor (CNTF) were found to be pleiotropic modulators of Sertoli cell and gonocyte development (both isolated from the neonatal rat testis) in a coculture system, whereas IL-6, another member of this cytokine family, had no effect on these cells. LIF and CNTF significantly enhanced the survival of the Sertoli cells in a dose- and time-dependent manner. The effect of LIF on the Sertoli cells was significant at a concentration of 1 ng/ml… CONTINUE READING
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