Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.

@article{Sempowski2000LeukemiaIF,
  title={Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.},
  author={Gregory D Sempowski and Laura P. Hale and John S. Sundy and Janice M. Massey and Richard A. Koup and Daniel C. Douek and Dhavalkumar D. Patel and Barton F Haynes},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={2180-7}
}
The roles that thymus cytokines might play in regulating thymic atrophy are not known. Reversing thymic atrophy is important for immune reconstitution in adults. We have studied cytokine mRNA steady-state levels in 45 normal human (aged 3 days to 78 years) and 34 myasthenia gravis thymuses (aged 4 to 75 years) during aging, and correlated cytokine mRNA… CONTINUE READING