Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

@article{Modlich2008LeukemiaIA,
  title={Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16},
  author={Ute Modlich and A Schambach and Martijn H. Brugman and Daniel Wicke and Sabine Knoess and Z Li and Tobias Maetzig and Cornelia Rudolph and Brigitte Schlegelberger and Christopher Baum},
  journal={Leukemia},
  year={2008},
  volume={22},
  pages={1519-1528}
}
Insertional activation of cellular proto-oncogenes by replication-defective retroviral vectors can trigger clonal dominance and leukemogenesis in animal models and clinical trials. Here, we addressed the leukemogenic potential of vectors expressing interleukin-2 receptor common γ-chain (IL2RG), the coding sequence required for correction of X-linked severe combined immunodeficiency. Similar to conventional γ-retroviral vectors, self-inactivating (SIN) vectors with strong internal enhancers also… 
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TLDR
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TLDR
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