Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses.

@article{Cignetti2004LeukemiaderivedID,
  title={Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses.},
  author={Alessandro Cignetti and Antonella Vallario and Ilaria Roato and Paola Circosta and Bernardino Allione and Laura Casorzo and Paolo Ghia and Federico Caligaris-Cappio},
  journal={Journal of immunology},
  year={2004},
  volume={173 4},
  pages={2855-65}
}
Primary acute myeloid leukemia cells can be induced to differentiate into dendritic cells (DC). In the presence of GM-CSF, TNF-alpha, and/or IL-4, leukemia-derived DC are obtained that display features of immature DC (i-DC). The aim of this study was to determine whether i-DC of leukemic origin could be further differentiated into mature DC (m-DC) and to evaluate the possibility that leukemic m-DC could be effective in vivo as a tumor vaccine. Using CD40L as maturating agent, we show that… CONTINUE READING

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