Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line.

Abstract

A growth factor was found in the supernatants of MOLT-4f, a cell line derived from acute T lymphoblastic leukemia. This factor, which we designated leukemia-derived growth factor from MOLT-4f (LDGF-M4), is different from interleukin 2. LDGF-M4 has features of a polypeptide with a molecular weight in the range of 5,000-15,000, as indicated by gel diffusion chromatography. LDGF-M4 does stimulate MOLT-4f and at least two other T cell lines that do not respond to interleukin 2. Because MOLT-4f cells produce and respond to LDGF-M4, this factor may contribute to the independence of MOLT-4f and related T leukemia cell lines.

Cite this paper

@article{Uittenbogaart1982LeukemiaderivedGF, title={Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line.}, author={Christel H. Uittenbogaart and John L . Fahey}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1982}, volume={79 22}, pages={7004-8} }