Leukemia Inhibitory Factor and Human Embryo Implantation

  title={Leukemia Inhibitory Factor and Human Embryo Implantation},
  author={Lusine Aghajanova},
  journal={Annals of the New York Academy of Sciences},
  • L. Aghajanova
  • Published 1 December 2004
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: The success of embryonic implantation relies on an ideal cross‐talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differentiation of mouse myeloid leukemic M1 cells into macrophages and later proposed as a marker of the embryo implantation process. An important role for LIF in implantation… 
Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment
Mechanisms at play and their relative importance to the establishment of pregnancy are discussed.
Current aspects of leukemia inhibitory factor (LIF) and its signaling pathways in choriocarcinoma cell lines
To better clarify the role of LIF and the JAK/STAT pathway in choriocarcinoma cell lines, which are considered models for studying trophoblast physiology, flow cytometry has been used to quantify cell proliferation, migration and invasion rates.
Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy Loss
The data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy, particularly in mice treated with PEGLA.
Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
Up-to-date information on the role of LIF in implantation and its role in contraception is summarized.
Embryo implantation: Shedding light on the roles of ovarian hormones, cytokines and growth factors in the implantation process
This review describes the implantation process and highlights the potential roles of some cytokines and growth factors (such as leukemia inhibitory factor, interleukin-1, inter Leukaemia-like growth factor system), which are involved in embryo-maternal interactions during the implantations process.
Decreased Endometrial Expression of Leukemia Inhibitory Factor Receptor Disrupts the STAT3 Signaling in Adenomyosis During the Implantation Window
Significant reduction in LIFR expression and the reduced activation of subsequent signaling strongly suggest a working model of how the implantation markers, LIF, may affect the endometrium of patients with adenomyosis.
Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice
The data suggest that LIF plays an important role in trophoblast invasion in vivo and may facilitate troPHoblast-decidual-immune cell cross talk to enable adequate spiral artery remodeling.
Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species
  • K. Raheem
  • Biology
    International journal of veterinary science and medicine
  • 2018
Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin αVβ3 and αVβ5.
It is suggested that Benzoic acid has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.


Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation.
The results suggest that uterine expression of LIF in humans, like mice, may have a role in regulating embryo implantation, possibly through an autocrine/paracrine interaction between LIF and its receptor at the luminal epithelium.
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium.
Implantation is the process by which the blastocyst becomes intimately connected with the maternal endometrium/decidua. The independently developing preimplantation blastocyst then becomes dependent
The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation.
It is found that LIF markedly decreased trophoblast production of hCG protein at 72 and 96 h, as well as expression of beta hCG mRNA and secretion of the protein, which are characteristic of cytotrophoblast differentiation toward an anchoring extravillous phenotype.
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
It is reported that transient expression of LIF in mice is essential for implantation, and females lacking a functional LIF gene are fertile, but their blastocysts fail to implant and do not develop.
Localization of leukemia inhibitory factor and its receptor in human placenta throughout pregnancy.
Fetal endothelial cells and all cells of the trophoblast lineage are identified as targets for the action of LIF in human placenta, and LIF appears to mediate interactions between maternal decidual leukocytes and invading trophOBlast.
Expression of leukemia inhibitory factor in human endometrium and placenta.
Findings suggest that, in humans, LIF plays a role in uterine function during the menstrual cycle, as well as during pregnancy.
Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation
Uterine receptivity is under dual control and is regulated by both the onset of LIF expression in the endometrial glands and the release from inhibition of receptor function in the LE, which regulates temporally the responsiveness of the LE to LIF.
Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time.
It is indicated that at the time of implantation in humans, the maternal endometrium produces LIF and that the blastocyst expresses LIF receptor mRNA and therefore may be capable of responding to this signal.
Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period.
Since CG is capable of stimulating trophoblast growth and differentiation as well as placental metabolism, LIF produced at the fetomaternal interface are considered to stimulate the trophoblasts to produce CG, which may contribute to the maintenance of the placental functions and embryonal growth.