Leukemia Inhibitory Factor and Human Embryo Implantation

@article{Aghajanova2004LeukemiaIF,
  title={Leukemia Inhibitory Factor and Human Embryo Implantation},
  author={Lusine Aghajanova},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1034}
}
  • L. Aghajanova
  • Published 1 December 2004
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: The success of embryonic implantation relies on an ideal cross‐talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differentiation of mouse myeloid leukemic M1 cells into macrophages and later proposed as a marker of the embryo implantation process. An important role for LIF in implantation… 
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This review describes the implantation process and highlights the potential roles of some cytokines and growth factors (such as leukemia inhibitory factor, interleukin-1, inter Leukaemia-like growth factor system), which are involved in embryo-maternal interactions during the implantations process.
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Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species
  • K. Raheem
  • Biology
    International journal of veterinary science and medicine
  • 2018
Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin αVβ3 and αVβ5.
TLDR
It is suggested that Benzoic acid has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.
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TLDR
The results suggest that uterine expression of LIF in humans, like mice, may have a role in regulating embryo implantation, possibly through an autocrine/paracrine interaction between LIF and its receptor at the luminal epithelium.
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Implantation is the process by which the blastocyst becomes intimately connected with the maternal endometrium/decidua. The independently developing preimplantation blastocyst then becomes dependent
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TLDR
It is found that LIF markedly decreased trophoblast production of hCG protein at 72 and 96 h, as well as expression of beta hCG mRNA and secretion of the protein, which are characteristic of cytotrophoblast differentiation toward an anchoring extravillous phenotype.
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TLDR
It is reported that transient expression of LIF in mice is essential for implantation, and females lacking a functional LIF gene are fertile, but their blastocysts fail to implant and do not develop.
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TLDR
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TLDR
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TLDR
Uterine receptivity is under dual control and is regulated by both the onset of LIF expression in the endometrial glands and the release from inhibition of receptor function in the LE, which regulates temporally the responsiveness of the LE to LIF.
Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time.
TLDR
It is indicated that at the time of implantation in humans, the maternal endometrium produces LIF and that the blastocyst expresses LIF receptor mRNA and therefore may be capable of responding to this signal.
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TLDR
Since CG is capable of stimulating trophoblast growth and differentiation as well as placental metabolism, LIF produced at the fetomaternal interface are considered to stimulate the trophoblasts to produce CG, which may contribute to the maintenance of the placental functions and embryonal growth.
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