Leukemia-Blast Crisis Cells Mesylate-sensitive or-refractory Chronic Myelogenous Bcr-Abl and Induces Apoptosis of Imatinib Expression and Promotes Proteasomal Degradation of Histone Deacetylase Inhibitor LAQ 824 Both Lowers

Abstract

Treatment with LAQ824 (Novartis Pharmaceutical, Inc.), a cinnamyl hydroxamic acid analogue inhibitor of histone deacetylases, depleted the mRNA and protein expression of Bcr-Abl in human chronic myeloid leukemia blast crisis (CML-BC) cells. Exposure to LAQ824 induced the expression of the cell cycle-dependent kinase inhibitors p21 and p27 and caused cell… (More)

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