Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

@inproceedings{McKerrell2015LeukemiaAssociatedSM,
  title={Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis},
  author={Thomas McKerrell and Naomi Park and Thaidy Moreno and Carolyn S Grove and Hannes Ponstingl and Jonathan C. Stephens and Charles R. Crawley and Jenny I O Craig and M. A. Scott and Clare Hodkinson and Joanna Baxter and Roland Rad and Duncan R. Forsyth and Michael A. Quail and Eleftheria Zeggini and Willem H Ouwehand and Ignacio Varela and George S Vassiliou},
  booktitle={Cell reports},
  year={2015}
}
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequencing. Using only the hot spots studied, we identified clonal hemopoiesis in 0.8% of individuals under 60, rising to 19.5% of those ≥90 years, thus predicting that clonal hemopoiesis is much more prevalent than previously realized. DNMT3A-R882 mutations were… CONTINUE READING

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Clonal hemopoiesis driven by leukemia - associated gene mutations can occur without evidence of a blood disorder .
Clonal hemopoiesis driven by leukemia - associated gene mutations can occur without evidence of a blood disorder .
Clonal hemopoiesis driven by leukemia - associated gene mutations can occur without evidence of a blood disorder .
Clonal hemopoiesis driven by leukemia - associated gene mutations can occur without evidence of a blood disorder .
Clonal hemopoiesis driven by leukemia - associated gene mutations can occur without evidence of a blood disorder .
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