Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho

@article{Fukuhara2000LeukemiaassociatedRG,
  title={Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho},
  author={Shigetomo Fukuhara and Hiroki Chikumi and J. Silvio Gutkind},
  journal={FEBS Letters},
  year={2000},
  volume={485}
}
A putative guanine nucleotide exchange factor (GEF), termed leukemia‐associated RhoGEF (LARG), was recently identified upon fusion to the coding sequence of the MLL gene in acute myeloid leukemia. Although the function of LARG is still unknown, it exhibits a number of structural domains suggestive of a role in signal transduction, including a PDZ domain, a LH/RGS domain, and a Dbl homology/pleckstrin homology domain. Here, we show that LARG can activate Rho in vivo. Furthermore, we present… 
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The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and
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TLDR
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Regulation of Rho guanine nucleotide exchange factors by G proteins.
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The regulation provided by this family of guanine nucleotide exchange factors for Rho proteins is defined by their selective regulation by specific G proteins, phosphorylation by kinases, and potential localization with signaling partners.
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