Leukemia: stem cells, maturation arrest, and differentiation therapy.

@article{Sell2005LeukemiaSC,
  title={Leukemia: stem cells, maturation arrest, and differentiation therapy.},
  author={Stewart Sell},
  journal={Stem cell reviews},
  year={2005},
  volume={1 3},
  pages={197-205}
}
Human myeloid leukemias provide models of maturation arrest and differentiation therapy of cancer. The genetic lesions of leukemia result in a block of differentiation (maturation arrest) that allows myeloid leukemic cells to continue to proliferate and/or prevents the terminal differentiation and apoptosis seen in normal white blood cells. In chronic… CONTINUE READING