Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro.

@article{Sugiura2000LeukaemiaIF,
  title={Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro.},
  author={Shigeki Sugiura and R Lahav and J Han and Su-ru Kou and Lisa R Banner and Flora de Pablo and Paul H. Patterson},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 2},
  pages={457-66}
}
The cytokine leukaemia inhibitory factor (LIF) is up-regulated in glial cells after injury to the peripheral and central nervous systems. In addition, LIF is required for the changes in neuropeptide expression that normally occur when the axons of sympathetic and sensory neurons are transected. We investigated whether LIF is also necessary for the initial inflammatory response that follows mechanical injury to the sciatic nerve and cerebral cortex of adult mice. We find that inflammatory cell… CONTINUE READING
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