Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

@article{Moreau1988LeukaemiaIF,
  title={Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells},
  author={Jean François Moreau and Debra D. Donaldson and F Bennett and J S Witek-Giannotti and Steven C. Clark and Gordon G. Wong},
  journal={Nature},
  year={1988},
  volume={336},
  pages={690-692}
}
Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine Ml myeloid leukaemia cell line1,2. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3–5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at… 
Protein factors that regulate the growth and differentiation of mouse myeloid leukaemia cells.
TLDR
Several protein factors that regulate the growth and differentiation of mouse myeloid leukaemia M1 cells have been purified and characterized and Regulation by these protein factors together with other known cytokines of growth and differentiated cells is reported.
The leukemia inhibitory factor (LIF).
  • D. Metcalf
  • Biology
    International journal of cell cloning
  • 1991
TLDR
The polyfunctionality of LIF suggests strongly that it is normally intended to be produced locally and act as a local regulator, and remains a promising candidate for clinical use in thrombocytopenia and myeloid leukemia.
Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells.
TLDR
Evidence is provided that LIF/DIA may play an important role, along with IL-6 and G-CSF, in the regulation of early hematopoietic stem cells.
Comparison of factors which induce differentiation of the murine myeloid leukaemic cell line M1.
  • D. Gearing
  • Biology, Medicine
    Haematology and blood transfusion
  • 1989
TLDR
The genetic and polypeptide structures of LIF are compared with those of two growth factors also known to cause differentiation of Ml cells: G-CSF and interleukin-6 (IL-6; MGI-2).
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
  • T. Rose, A. Bruce
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
It is proposed that OSM, LIF, G-CSF, and IL-6 are structurally related members of a cytokine family that have in common the ability to modulate differentiation of a variety of cell types.
Leukemia inhibitory factor/human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors.
TLDR
LIF/HILDA is a novel cytokine capable of stimulating growth and proliferation of multi-lineage, erythroid, and eosinophil colonies in the presence of serum and has an additive effect when used with other cytokines known to stimulate primitive hematopoietic precursors, and does not require accessory cells.
In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: differential regulation by interleukin-1 alpha and glucocorticoids.
TLDR
The production and the regulation of the production of leukemia inhibitory factor/human interleukin for DA cells (LIF/HILDA) by EC is examined and it is shown that HBMEC are quantitatively a very important source of this cytokine suggesting that they are a major source of LIF/ HILDA in the bone marrow.
Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.
TLDR
Combination of LIF with multipotential-colony-stimulating factor (Multi-CSF) (interleukin-3) enhanced the megakaryocyte colony formation able to be stimulated by Multi- CSF; the enhancement involved all types of megakARYocyte colony and resulted in the formation of increased numbers ofmegakaryocytes.
Leukemia Inhibitory Factor: Does the Cap Fit? a
  • D. Gearing
  • Biology
    Annals of the New York Academy of Sciences
  • 1991
TLDR
It was hoped that the availability of large amounts of recombinant LIF would help lead to an understanding of the role(s) of LIF in the hematopoietic and other systems, and it was reasonable to suggest that it had some normal purpose within the mammal.
Leukemia Inhibitory Factor in Human Reproduction
TLDR
Although named for its ability to inhibit proliferation of a myeloid leukemic cell line by inducing differentiation, LIF also regulates the growth and differentiation of embryonic stem cells, primordial germ cells, peripheral neurons, osteoblasts, adipocytes, and endothelial cells.
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References

SHOWING 1-10 OF 20 REFERENCES
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).
TLDR
Cloning, sequencing and expressing LIF has resolved several discrepancies in the literature concerning the identity of factors capable of inducing differentiation of murine myeloid leukaemic cells in vitro.
Stimulation of murine hemopoietic colony formation by human IL-6.
TLDR
The range of known target cells of IL-6 is expanded to include hemopoietic progenitors in addition to B cells, T cells, and fibroblasts and provide further evidence that this cytokine plays an important role within a network of interacting cytokines that regulates many different biologic responses.
Characterization of a factor produced by human T cell clones exhibiting eosinophil-activating and burst-promoting activities.
TLDR
Highly purified HILDA turned out to be a potent chemoattractant and activator of, respectively, mouse and human eosinophils and burst-promoting activity on human marrow.
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.
TLDR
A human homologue of the recently cloned murine leukemia-inhibitory factor (LIF) gene was isolated from a genomic library by using the murine cDNA as a hybridization probe and could be induced with galactose to produce high levels of a factor that induced the differentiation of murine M1 leukemic cells in a manner analogous to murine LIF.
T-cell growth factor gene: lack of expression in human T-cell leukemia-lymphoma virus-infected cells.
TLDR
It is reported that cells infected with human T-cell leukemia-lymphoma virus also lack detectable TCGF messenger RNA and thus do not produce their own growth factor, which apparently rule out an autostimulation mechanism of growth control.
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