Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo.

@article{Stewart1994LeukaemiaIF,
  title={Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo.},
  author={Colin Lawson Stewart},
  journal={Molecular reproduction and development},
  year={1994},
  volume={39 2},
  pages={233-8}
}
This paper reviews the evidence that certain growth factors, particularly leukaemia inhibitory factor (LIF), play a crucial role in regulating the development of the pre-implantation mammalian embryo. LIF was originally implicated in regulating the early development of the mouse embryo because it inhibited the differentiation of embryonic stem (ES) cells, pluripotential cells derived from the inner cell mass of the blastocyst. Subsequent studies on its role in vivo revealed, surprisingly, that… CONTINUE READING

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