Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells


The precise identity of a tumour's cell of origin can influence disease prognosis and outcome. Methods to reliably define tumour cell of origin from primary, bulk tumour cell samples has been a challenge. Here we use a well-defined model of MLL-rearranged acute myeloid leukaemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and… (More)
DOI: 10.1038/ncomms12166


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