Leucovorin, 5-fluorouracil, and gemcitabine: A phase I study

  title={Leucovorin, 5-fluorouracil, and gemcitabine: A phase I study},
  author={Elizabeth A. Poplin and John M K Roberts and Marybeth Tombs and Steven Grant and Eric D Rubin},
  journal={Investigational New Drugs},
Gemcitabine is a chemotherapy agent with efficacy in the treatment of lung, pancreas, bladder and breast cancer. It inhibits DNA synthesis by interfering with cytidine triphosphate production and also inhibits the activity of ribonucleotide reductase. Gemcitabine may potentiate fluorouracil's inhibition of thymidylate synthase. This inhibition would be expected to be sequence dependent, occurring only if gemcitabine were administered following fluorouracil (5FU). The combination of leucovorin… CONTINUE READING