Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice.

@article{Nairizi2009LeucineSO,
  title={Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice.},
  author={Ali Nairizi and Pengxiang She and Thomas C. Vary and Christopher J. Lynch},
  journal={The Journal of nutrition},
  year={2009},
  volume={139 4},
  pages={715-9}
}
Branched-chain amino acids (BCAA), Leu, and the signaling pathways they regulate have been reported to either improve or worsen adiposity and insulin sensitivity. Therefore, it is unclear whether dietary supplementation of Leu would be beneficial. To help address this question, we examined the effect of adding Leu (150 mmol/L; Expt. 1 and Expt. 2) or BCAA (109 mmol/L of each; Expt. 3) to the drinking water on diet-induced obesity (induced with a 60-kJ% fat diet) in singly housed C57BL6/J male… CONTINUE READING
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