Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells.

@article{Tomiya2002LeucineST,
  title={Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells.},
  author={Tomoaki Tomiya and Yukiko Inoue and Mikio Yanase and Masahiro Arai and Hitoshi Higashiosaka-shi Ikeda and Kazuaki Tejima and Kayo Nagashima and Tetsuo Nishikawa and Kenji Fujiwara},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={297 5},
  pages={
          1108-11
        }
}
Branched-chain amino acids (BCAAs) modulate various cellular functions, in addition to providing substrates for the production of proteins. In this study, we examined the effect of BCAAs on the secretion of hepatocyte growth factor (HGF) by hepatic stellate cells. A hepatic stellate cell clone was cultured in medium supplemented with various concentrations of valine, leucine, or isoleucine. Of these BCAAs, leucine markedly induced an increase in the levels of HGF in the medium in a dose… CONTINUE READING
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