Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions

@inproceedings{Greggio2009LeucinerichRK,
  title={Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions},
  author={Elisa Greggio and Mark R Cookson},
  booktitle={ASN neuro},
  year={2009}
}
Mutations in the gene encoding LRRK2 (leucine-rich repeat kinase 2) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson's disease. The protein is a large GTP-regulated serine/threonine kinase that additionally contains several protein-protein interaction domains. In the present review, we discuss three important, but unresolved, questions concerning LRRK2. We first ask: what is the normal function of LRRK2? Related to this, we… CONTINUE READING

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LRRK2 geneGene associated with diseaseParkinson Disease
Mutations in the gene encoding LRRK2 ( leucine - rich repeat kinase 2 ) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson 's disease .
Mutations in the gene encoding LRRK2 ( leucine - rich repeat kinase 2 ) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson 's disease .
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