Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.

  title={Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.},
  author={N. Barker and H. Clevers},
  volume={138 5},
  • N. Barker, H. Clevers
  • Published 2010
  • Medicine, Biology
  • Gastroenterology
  • Molecular markers are used to characterize and track adult stem cells. Colon cancer research has led to the identification of 2 related receptors, leucine-rich repeat-containing, G-protein-coupled receptors (Lgr)5 and Lgr6, that are expressed by small populations of cells in a variety of adult organs. Genetic mouse models have allowed the visualization, isolation, and genetic marking of Lgr5(+ve) and Lgr6(+ve) cells and provided evidence that they are stem cells. The Lgr5(+ve) cells were found… CONTINUE READING
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