Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality.

@article{Mazerbourg2004LeucinerichRG,
  title={Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality.},
  author={Sabine Mazerbourg and Donna Michelle Bouley and Satoko Sudo and Cynthia A Klein and Jian V. Zhang and Kazuhiro Kawamura and Lisa V Goodrich and Helen Rayburn and Marc Tessier-Lavigne and Aaron J Hsueh},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 9},
  pages={2241-54}
}
Leucine-rich repeat-containing, G protein-coupled receptors (LGRs) belong to the largest mammalian superfamily of proteins with seven-transmembrane domains. LGRs can be divided into three subgroups based on their unique domain arrangement. Although two subgroups have been found to be receptors for glycoprotein hormones and relaxin-related ligands, respectively, the third LGR subgroup, consisting of LGR4-6, are orphan receptors with unknown physiological roles. To elucidate the functions of this… CONTINUE READING
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