Leucine-rich nuclear-export signals: born to be weak.

  title={Leucine-rich nuclear-export signals: born to be weak.},
  author={Ulrike Kutay and Stephan G{\"u}ttinger},
  journal={Trends in cell biology},
  volume={15 3},
CRM1 mediates the nuclear export of proteins exposing leucine-rich nuclear-export signals (NESs). Most NESs bind to CRM1 with relatively low affinity. Recently, higher-affinity NESs were selected from a 15-mer random peptide library. Unexpectedly, complexes between high-affinity NESs and CRM1 accumulate at the cytoplasmic filaments of the nuclear pore complex (NPC). This finding suggests that high-affinity NES binding to CRM1 impairs the efficient release of export complexes from the NPC… CONTINUE READING
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