Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.

@article{Wilson2011LeucineOC,
  title={Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.},
  author={Gabriel J. Wilson and Donald K Layman and Christopher J. Moulton and Layne E. Norton and Tracy G Anthony and Christopher G Proud and S Indu Rupassara and Peter J. Garlick},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={301 6},
  pages={E1236-42}
}
Muscle protein synthesis (MPS) increases after consumption of a protein-containing meal but returns to baseline values within 3 h despite continued elevations of plasma amino acids and mammalian target of rapamycin (mTORC1) signaling. This study evaluated the potential for supplemental leucine (Leu), carbohydrates (CHO), or both to prolong elevated MPS after a meal. Male Sprague-Dawley rats (∼270 g) trained to consume three meals daily were food deprived for 12 h, and then blood and… CONTINUE READING
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Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibi E1241 POSTPRANDIAL MPS EXTENDED WITH Leu OR CHO SUPPLEMENTS AJP-Endocrinol Metab

  • M Du, QW Shen, MJ Zhu, SP. Ford
  • J Anim Sci
  • 2011
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