Leucine and HMB Differentially Modulate Proteasome System in Skeletal Muscle under Different Sarcopenic Conditions

Abstract

In the present study we have compared the effects of leucine supplementation and its metabolite β-hydroxy-β-methyl butyrate (HMB) on the ubiquitin-proteasome system and the PI3K/Akt pathway during two distinct atrophic conditions, hindlimb immobilization and dexamethasone treatment. Leucine supplementation was able to minimize the reduction in rat soleus… (More)
DOI: 10.1371/journal.pone.0076752

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@inproceedings{Baptista2013LeucineAH, title={Leucine and HMB Differentially Modulate Proteasome System in Skeletal Muscle under Different Sarcopenic Conditions}, author={Igor Luchini Baptista and Willian Jos{\'e} Rodrigues da Silva and Guilherme Giannini Artioli and J. Guilherme and Marcelo Larciprete Leal and Marcelo Saldanha Aoki and Elen Haruka Miyabara and Anselmo Sigari Moriscot}, booktitle={PloS one}, year={2013} }