Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

@inproceedings{Ness2013LeucineRichRK,
  title={Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis},
  author={Daniel W. Van Ness and Zhao Hua Ren and Shyra J. Gardai and Douglas D. Sharpnack and Victor Johnnie Johnson and Richard J. Brennan and Elizabeth F. Brigham and Andrew J. Olaharski},
  booktitle={PloS one},
  year={2013}
}
Genetic evidence links mutations in the LRRK2 gene with an increased risk of Parkinson's disease, for which no neuroprotective or neurorestorative therapies currently exist. While the role of LRRK2 in normal cellular function has yet to be fully described, evidence suggests involvement with immune and kidney functions. A comparative study of LRRK2-deficient and wild type rats investigated the influence that this gene has on the phenotype of these rats. Significant weight gain in the LRRK2 null… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

LRRK2 inhibition attenuates microglial inflammatory responses.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2012