Leucine‐rich α‐2 glycoprotein promotes lung fibrosis by modulating TGF‐β signaling in fibroblasts

@inproceedings{Honda2017LeucinerichG,
  title={Leucine‐rich α‐2 glycoprotein promotes lung fibrosis by modulating TGF‐β signaling in fibroblasts},
  author={Hiromi Honda and Minoru Fujimoto and Satoshi Serada and Hayato Urushima and Takashi Mishima and Hyun Don Lee and Tomoharu Ohkawara and Nobuoki Kohno and Noboru Hattori and Akihito Yokoyama and Tetsuji Naka},
  booktitle={Physiological reports},
  year={2017}
}
TGF-β has an important role in fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Detailed analysis of TGF-β signaling in pulmonary fibrosis at the molecular level is needed to identify novel therapeutic targets. Recently, leucine-rich alpha-2 glycoprotein (LRG) was reported to function as a modulator of TGF-β signaling in angiogenesis and tumor progression. However, the involvement of LRG in fibrotic disorders, including IPF, has not yet been investigated. In this study, we… CONTINUE READING