LeuT: a prokaryotic stepping stone on the way to a eukaryotic neurotransmitter transporter structure.

@article{Singh2008LeuTAP,
  title={LeuT: a prokaryotic stepping stone on the way to a eukaryotic neurotransmitter transporter structure.},
  author={Satinder K. Singh},
  journal={Channels},
  year={2008},
  volume={2 5},
  pages={380-9}
}
Ion-coupled secondary transport is utilized by a broad range of integral membrane proteins to catalyze the energetically unfavorable movement of solute molecules across a lipid bilayer. Members of the solute carrier 6 (SLC6) family, present in both prokaryotes and eukaryotes, are sodium-coupled symporters that play crucial roles in processes as diverse as nutrient uptake and neurotransmitter clearance. The crystal structure of LeuT, a bacterial member of this family, provided the first atomic… CONTINUE READING