Letter to the Editor: Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor

  title={Letter to the Editor: Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor},
  author={Shih-Che Sue and Jeou‐Yuan Chen and Tai-Huang Huang},
  journal={Journal of Biomolecular NMR},
Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton
Two previously unknown HDGF isoforms are described, generated via alternative splicing with structurally unrelated N-terminal regions of their hath region, which are clearly different from the well described HDGF-A.


Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.
Findings suggest that the hepatoma-derived growth factor is a novel heparin-binding protein, with mitogenic activity for fibroblasts, withlay in several tumor-derived cell lines, as well as in normal tissues.
Structural variation in PWWP domains.
Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus.
Northern blotting shows that mouse HDGF and HRP-2 are expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen, suggesting that the HDGF gene family might play a new role in the nucleus especially in testes.
Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer.
It is shown that HDGF may play an important role in radiosensitivity, and it could be a novel marker predicting effectiveness of radiotherapy in clinical cases, and was more effective in clinical Cases with high HDGF mRNA expression compared with cases with low expression.
The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies.
Comparing the bHRP-4 amino acid sequence with HRP-1-3 and p52/75/lens epithelium-derived growth factor (LEDGF) shows that these proteins share a conserved N-terminal part of 91 amino acids but have C-termini of different lengths and charge, which demonstrates the modular structure of these proteins and allows its classification into three groups based on charge, size and sequence comparison.
Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development.
It is demonstrated that HDGF mRNA is expressed in smooth muscle cells (SMCs), most prominently in proliferating SMCs, 8-24 hours after serum stimulation, and colocalizes with the proliferating cell nuclear antigen (PCNA) in SMCs in human atherosclerotic carotid arteries, suggesting thatHDGF helps regulate SMC growth during development and in response to vascular injury.