Letter to U.S. FDA Commissioner

  title={Letter to U.S. FDA Commissioner},
  author={Kamal M. Abdo and Carlos A. Camargo and Devra Lee Davis and David S. Egilman and Samuel S. Epstein and John R. Froines and Dale B. Hattis and Kim Hooper and James Huff and Peter F Infante and Michael F Jacobson and Daniel Thau Teitelbaum and Joel A. Tickner},
  journal={International Journal of Occupational and Environmental Health},
  pages={449 - 450}
  • K. Abdo, C. Camargo, +10 authors J. Tickner
  • Published 1 October 2007
  • Medicine
  • International Journal of Occupational and Environmental Health
An important new long-term animal feeding study, published in Environmental Health Perspectives, from the Cesare Maltoni Cancer Research Center at the European Ramazzini Foundation of Oncology and Environmental Sciences in Italy, raises anew serious questions about the safety of the artificial sweetener aspartame.1 Dose-dependent increases in total malignant tumors, lymphomas/leukemias, and mammary carcinomas were observed in male and/ or female rats. At the higher dosage level, the increases… 
The Limits of Two-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens
It is proposed that the sensitivity of chemical carcinogenesis bio-assays would be enhanced by exposing rodents beginning in utero and continuing exposure for 30 months or until their natural deaths, and to strengthen the value and validity of results for regulatory agencies.
Aspartame Bioassay Findings Portend Human Cancer Hazards
  • J. Huff, Ladou Ladou
  • Medicine
    International journal of occupational and environmental health
  • 2007
The U.S. Food and Drug Administration should reevaluate its position on aspartame as being safe under all conditions and consider sponsoring a prospective epidemiologic study of aspartam workers.
Características de los edulcorantes no calóricos y su uso en niños
This is a descriptive review of the elaboration routes, the physical and chemical characteristics, metabolism and clearance, sweetener level, residual flavor, maximal recommended ingestion, security


First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats
APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake, and a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed.
Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats
The results of this carcinogenicity bioassay confirm and reinforce the first experimental demonstration of APM’s multipotential carcinogensicity at a dose level close to the acceptable daily intake for humans.
statement on European aspartame study
  • April 20,
  • 2007
Liquid Candy-Supplement (Center for Science in the Public Interest
  • 2005
A Coca-Cola website indicates that a diet soda contains 175 mg of aspartame
FDA statement on European aspartame study