Letter: Ascorbic acid-induced hemolysis in G-6-PD deficiency.

  title={Letter: Ascorbic acid-induced hemolysis in G-6-PD deficiency.},
  author={G. Douglas Campbell and Martin H Steinberg and John D Bower},
  journal={Annals of internal medicine},
  volume={82 6},
THOUGH THE ORIGINS of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are rooted in human antiquity, the presence of drug-induced hemolysis in individuals subsequently felt to have G-6-PD deficiency was first reported in 1926 and the biochemical lesion responsible for this phenomenon elucidated in 1956 (1). In the United States, hemolysis induced by infection or drugs is the most common clinical manifestation of G-6-PD deficiency (2). Ascorbic acid (vitamin C), an essential… CONTINUE READING


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