Letrozole versus clomiphene citrate in polycystic ovary syndrome: a meta-analysis of randomized controlled trials

@article{Hu2018LetrozoleVC,
  title={Letrozole versus clomiphene citrate in polycystic ovary syndrome: a meta-analysis of randomized controlled trials},
  author={Shi-fu Hu and Qiong Yu and Yingying Wang and Mei Wang and Wei Xia and Changhong Zhu},
  journal={Archives of Gynecology and Obstetrics},
  year={2018},
  volume={297},
  pages={1081-1088}
}
PurposePolycystic ovary syndrome (PCOS) is a common endocrine disturbance affecting women in the reproductive age group. The present study aimed to compare the effects of letrozole (LE) and clomiphene citrate (CC) for ovulation induction in women with PCOS.MethodsThe PUBMED, Web of Science, and EMBASE databases were screened systematically for randomized controlled trials (RCTs) published from database inception to July 2017.ResultsEleven RCTs involving 2255 patients were included, and data… Expand
Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis
TLDR
A higher probability of ovulation is expected in infertile patients with PCOS treated with letrozole as compared to clomiphene citrate, and the higher ovulation rate might have contributed to the higher clinical pregnancy and live birth rate. Expand
COMPARATIVE STUDY BETWEEN CLOMIPHINE CITRATE AND LETROZOLE FOR OVULATION INDUCTION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
TLDR
Letrozole is preferable on clomiphene citrate regarding higher pregnancy rate as well as monofollicles that will decrease the risk of multiple pregnancies which is clearly observed with clomine citrate. Expand
Letrozole for patients with polycystic ovary syndrome
TLDR
It is demonstrated that the efficacy of letrozole is not superior to the clomiphene in patients with PCOS, and no adverse events differ significantly between 2 groups. Expand
Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome
TLDR
Endometrial receptivity during the implantation window of LE is superior to CC in PCOS women, which may be related to higher clinical pregnancy and ongoing pregnancy rates. Expand
A Randomized Trial of Combined Letrozole with Metformin Versus Clomiphene Citrate with Metformin in Polycystic Ovary (PCOS) patients
TLDR
Both CC and letrozole are equally effective in treatment of infertility in PCOS patients, when combined with metformin treatment. Expand
Clomiphene-Metformin in Comparison with Letrozole-Metformin in Overweight Infertile Women with PCOS
TLDR
CC and letrozole are similarly viable in the treatment of overweight women with PCOS, when joined with metformin treatment. Expand
Changes in serum markers of patients with PCOS during consecutive clomiphene stimulation cycles: a retrospective study
TLDR
Two cycles of CC-stimulation that did not lead to a pregnancy were accompanied by mean LH, AMH, and LH:FSH ratio declines and an SHBG increase. Expand
Letrozole Therapy versus Extended Clomiphene Citrate Therapy for Induction of Ovulation in Resistant Patients with Polycystic Ovarian Syndrome in Low Resource Communities
TLDR
It was revealed that use of letrozole or extended treatment with clomiphene did not show better outcomes over each other in number of growing follicles, ovulation rates, occurrence of pregnancy and pregnancy outcomes. Expand
Management Options for Infertile Women with Polycystic Ovary Syndrome
TLDR
Clinical decisions in PCOS anovulatory patients are currently supported by a recently published international evidence-based guideline that provides 166 recommendations to help clinicians in the diagnosis and management of PCOS and to guide clinical practice. Expand
The Role of Letrozole (LE) in Controlled Ovarian Stimulation (COS) in Patients at High Risk to develop Ovarian Hyper Stimulation Syndrome (OHSS). A prospective randomized controlled pilot study.
TLDR
In PCOS patients with extremely high AMH levels the LE co-administration to Gn RH-Ant protocols results in reduced incidence of OHSS than conventional GnRH- Ant protocols, which may prove to be highly effective in preventing OHSS. Expand
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This study found that letrozole is superior to CC when considering the live birth and pregnancy rates in patients with PCOS. Expand
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The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Expand
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