Lethality of tyrosine in mice

  title={Lethality of tyrosine in mice},
  author={John C. David},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • J. C. David
  • Published 2004
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryHigh doses of tyrosine were found to be lethal in mice. The lethality was potentiated by decarboxylase inhibitors which acted by elevating tissues tyrosine levels when given together with large amounts of tyrosine. The lethality of either tyrosine or tyrosine given in combination with decarboxylase inhibitors was found to be correlated with the elevation of tyrosine levels in liver. This toxicity does not appear to involve either tyramine or p-hydroxyphenylpyruvic acid formation… Expand
Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system
  • J. C. David
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
It is concluded that the liver microsomal drug metabolizing system is capable of converting tyrosine to a toxic metabolite, conceivably a 2.3 epoxide of tyrosines, in relation to the human disease tyrosinemia. Expand
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The combined results of radioenzymatic assay and fluorescence histochemistry determinations demonstrated that clonidine markedly reduced noradrenaline turnover in central nor adrenaline-containing nerve terminals, but had no effect on the cell bodies of the A1 and A2 cell groups. Expand
Sodium ascorbate enhancement of carbidopa-levodopa methyl ester antitumor activity against pigmented B16 melanoma.
The data indicate that adding ascorbate and restricting tyrosine and phenylalanine in combination with levodopa methyl ester therapy may become an important strategy for treating malignant melanoma. Expand
Final Report of the Safety Assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as Used in Cosmetics1
  • A. Elmore
  • Chemistry, Medicine
  • International journal of toxicology
  • 2005
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