Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.

@article{Takahashi2017LethalityOM,
  title={Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.},
  author={Noriko Takahashi and Charley C. Gruber and Jason H Yang and Xiaobo Liu and Dana Braff and Chittampalli N Yashaswini and Sakkarin Bhubhanil and Yoshikazu Furuta and Silvana Andreescu and James J Collins and Graham C Walker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017}
}
Downstream metabolic events can contribute to the lethality of drugs or agents that interact with a primary cellular target. In bacteria, the production of reactive oxygen species (ROS) has been associated with the lethal effects of a variety of stresses including bactericidal antibiotics, but the relative contribution of this oxidative component to cell death depends on a variety of factors. Experimental evidence has suggested that unresolvable DNA problems caused by incorporation of oxidized… CONTINUE READING