Lethality and centrality in protein networks

  title={Lethality and centrality in protein networks},
  author={Hawoong Jeong and Spencer Mason and A. L. Barabasi and Zolt{\'a}n N. Oltvai},
Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in… Expand

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