Lethal mutagenesis of HIV.

  title={Lethal mutagenesis of HIV.},
  author={Robert Adamson Smith and L. A. Loeb and Bradley D. Preston},
  journal={Virus research},
  volume={107 2},
HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of "error catastrophe" or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here, we review the concept of extinguishing HIV infection by "lethal mutagenesis" and… CONTINUE READING
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The cytidine deaminase CEM 15 induces hypermutati newly synthesized HIV - 1 DNA

  • H. M. Temin
  • Nature
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