Lethal inflammasome activation by a multi-drug resistant pathobiont upon antibiotic disruption of the microbiota

@inproceedings{Ayres2012LethalIA,
  title={Lethal inflammasome activation by a multi-drug resistant pathobiont upon antibiotic disruption of the microbiota},
  author={Janelle S. Ayres and Norver J. Trinidad and Russell E Vance},
  booktitle={Nature Medicine},
  year={2012}
}
The mammalian intestine harbors a complex microbial community that provides numerous benefits to its host. However, the microbiota can also include potentially virulent species, termed pathobiont, which can cause disease when intestinal homeostasis is disrupted. The molecular mechanisms by which pathobionts cause disease remain poorly understood. Here we describe a sepsis-like disease that occurs upon gut injury in antibiotic-treated mice. Sepsis was associated with the systemic spread of a… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 70 references

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

Sander, L.E
Nature 474, • 2011

- residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells

H. J. Wu
Gut • 2010

Control of intestinal homeostasis, colitis and colitisassociated colorectal cancer by the inflammatory caspases

J Dupaul-Chicoine
Immunity 32, • 2010

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