Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones.

Abstract

When DNA gyrase is trapped on bacterial chromosomes by quinolone antibacterials, reversible complexes form that contain DNA ends constrained by protein. Two subsequent processes lead to rapid cell death. One requires ongoing protein synthesis; the other does not. The prototype quinolone, nalidixic acid, kills wild-type Escherichia coli only by the first… (More)

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Cite this paper

@article{Malik2006LethalFO, title={Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones.}, author={Muhammad Afzaal Malik and Xilin Zhao and Karl Drlica}, journal={Molecular microbiology}, year={2006}, volume={61 3}, pages={810-25} }