Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation.

Abstract

Cellular compartmentalization requires machinery capable of translocating polypeptides across membranes. In many cases, transported proteins must first be unfolded by means of the proton motive force and/or ATP hydrolysis. Anthrax toxin, which is composed of a channel-forming protein and two substrate proteins, is an attractive model system to study… (More)
DOI: 10.1073/pnas.0905880106

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