Lethal factor of Bacillus anthracis cleaves the N-terminus of MAPKKs: analysis of the intracellular consequences in macrophages.

@article{Pellizzari2000LethalFO,
  title={Lethal factor of Bacillus anthracis cleaves the N-terminus of MAPKKs: analysis of the intracellular consequences in macrophages.},
  author={Rosanan Pellizzari and Chantal Guidi-Rontani and Giustina Vitale and Mich{\`e}le E. Mock and Cesare Montecucco},
  journal={International journal of medical microbiology : IJMM},
  year={2000},
  volume={290 4-5},
  pages={421-7}
}
The lethal toxin of Bacillus anthracis consists of two proteins, PA and LF, which together induce lethal effects in some animal species and cause macrophage lysis. LF is a zinc-binding protein with metalloprotease activity. With a two-hybrid system approach we identified MAP kinase kinases (MAPKKs) Mekl and Mek2 as proteins interacting with LF. LF was shown to cleave Mek1 and Mek2 and an additional MAPKK family member MKK3, within their N-terminal region. We examined macrophage cell lines and… CONTINUE READING

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