Lethal factor is not required for Bacillus anthracis virulence in guinea pigs and rabbits.

@article{Levy2011LethalFI,
  title={Lethal factor is not required for Bacillus anthracis virulence in guinea pigs and rabbits.},
  author={Haim Levy and Shay Weiss and Zeev Altboum and Josef Schlomovitz and Nili Rothschild and Eran Blachinsky and David Kobiler},
  journal={Microbial pathogenesis},
  year={2011},
  volume={51 5},
  pages={
          345-51
        }
}
The major virulence factor of Bacillus anthracis is the tripartite anthrax toxin, comprising the protective antigen (PA), lethal factor (LF) and edema factor (EF). The LF of B. anthracis is a metalloprotease that has been shown to play an important role in pathogenicity. Deletion of this gene (lef) in the Sterne strain was reported to dramatically reduce the pathogenicity of this strain in mice, and was reported to be as dramatic as the deletion of PA. We evaluated the effect on pathogenicity… CONTINUE READING
BETA

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 17 REFERENCES

Toxin - de fi cient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax

  • Heninger SDM, J Lovchik, J Hutt, MF Lipscomb, TM Koehler, CR Lyons
  • Infection and Immunity
  • 2006

Toxindeficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax. Infection and Immunity 2006;74:6067e74

  • SDM Heninger, J Lovchik, J Hutt, MF Lipscomb, TM Koehler, CR. Lyons
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…