Lethal effects of apidaecin on Escherichia coli involve sequential molecular interactions with diverse targets.

@article{Castle1999LethalEO,
  title={Lethal effects of apidaecin on Escherichia coli involve sequential molecular interactions with diverse targets.},
  author={Michael Castle and Arpi Nazarian and Sun Shin Yi and Paul Tempst},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 46},
  pages={32555-64}
}
Apidaecins, short proline-arginine-rich peptides from insects, are highly bactericidal through a mechanism that includes stereoselective elements but is completely devoid of any pore-forming activity. The spectrum of antibacterial activity, always limited to Gram-negatives, is further dependent on a small number of variable residues and can be manipulated. We show here that mutations in the evolutionary conserved regions result in a more general loss of function, and we have used such analogs… CONTINUE READING

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