Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection.

@article{Cillniz2010LethalDO,
  title={Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection.},
  author={Cristian Cill{\'o}niz and Mary J Pantin-Jackwood and Chester Ni and Alan G Goodman and Xinxia Peng and Sean C. Proll and Victoria S. Carter and Elizabeth R Rosenzweig and Kristy J. Szretter and Jacqueline M. Katz and Marcus J. Korth and David Swayne and Terrence M. Tumpey and Michael G. Katze},
  journal={Journal of virology},
  year={2010},
  volume={84 15},
  pages={7613-24}
}
Periodic outbreaks of highly pathogenic avian H5N1 influenza viruses and the current H1N1 pandemic highlight the need for a more detailed understanding of influenza virus pathogenesis. To investigate the host transcriptional response induced by pathogenic influenza viruses, we used a functional-genomics approach to compare gene expression profiles in lungs from 129S6/SvEv mice infected with either the fully reconstructed H1N1 1918 pandemic virus (1918) or the highly pathogenic avian H5N1 virus… CONTINUE READING

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