Lethal deletion of the complement component C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by meiotic recombination.

@article{Shiroishi1987LethalDO,
  title={Lethal deletion of the complement component C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by meiotic recombination.},
  author={Toshihiko Shiroishi and Tomoko Sagai and Shunnosuke Natsuume-Sakai and Kazuo Moriwaki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 9},
  pages={2819-23}
}
A recombinant H-2 haplotype, designated aw18, was produced that underwent meiotic recombination in the E alpha (I-E alpha chain)--Slp (sex-limited protein) interval of the H-2 class III region between B10.A (H-2a) and wild-derived B10.MOL-SGR (H-2wm7) strains. It appeared that the H-2aw18 haplotype has a single, recessive, lethal mutation, since homozygotes for H-2aw18 were not detected in progeny generated from the intercross of mice that were heterozygous for this H-2 haplotype. Nine newly… CONTINUE READING
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