Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.

@article{Eriksson2001LethalAM,
  title={Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.},
  author={Urs Eriksson and Michael Odo Kurrer and R. Bingisser and H. P. Eugster and Parvin Saremaslani and Ferenc Follath and Stephan Marsch and Urs Widmer},
  journal={Circulation},
  year={2001},
  volume={103 1},
  pages={
          18-21
        }
}
BACKGROUND Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases. Little is known about its role in inflammatory heart disease. METHODS AND RESULTS We showed that IFN-gamma receptor-deficient mice (IFN-gammaR(-/-)) on a BALB/c background immunized with a peptide derived from cardiac alpha-myosin heavy chain develop severe myocarditis with high mortality. Although myocarditis subsided in wild-type mice after 3 weeks, IFN-gammaR… CONTINUE READING

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