Lethal Midline Granuloma-Nasal Natural Killer/T-Cell Lymphoma

  title={Lethal Midline Granuloma-Nasal Natural Killer/T-Cell Lymphoma},
  author={William M. Mendenhall and Kenneth R. Olivier and James W. Lynch and Nancy Price Mendenhall},
  journal={American Journal of Clinical Oncology},
Purpose:The purpose of this paper is to discuss lethal midline granuloma (LMG)-nasal natural killer (NK) T-cell lymphoma (LMG-NTL). Methods:Literature review. Results:LMG is a rare entity that usually arises in the nasal cavity, exhibits a male preponderance, and has a wide age range. The majority of LMGs are LMG-NTLs. The optimal treatment of LMG-NTL is unclear and is most likely moderate-dose radiotherapy. The prognosis for patients with LMG-NTL is significantly worse than for patients with… 
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Extranodal nasal‐type natural killer (NK)/T‐cell lymphoma is a very uncommon disease process often mimicking refractory sinusitis, and careful immunohistochemical evaluation is crucial to differentiate NK/T‐ cell lymphoma from other malignancies.
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Orofacial Granulomatosis: A Review
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Treatment of lethal midline granuloma type nasal T-cell lymphoma.
The data indicates that it is desirable to deliver 50 Gy or more to achieve in-field control of LMG-NTL.
Nasal peripheral T-cell lymphoma: a 20-year review of cases treated in Scotland.
Nasal-Type T/NK Lymphomas: A Clinicopathologic Study of 13 Cases
The response to doxorubicin-containing regimens is inferior to that of patients with other non-Hodgkin's lymphomas and similar prognostic factors.
Experience of radiotherapy in lethal midline granuloma with special emphasis on centrofacial T-cell lymphoma: a retrospective analysis covering a 34-year period.
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Report of the Workshop on Nasal and Related Extranodal Angiocentric T/Natural Killer Cell Lymphomas. Definitions, differential diagnosis, and epidemiology.
The participants concluded that nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity highly associated with Epstein-Barr virus (EBV) and in situ hybridization for EBV an be very valuable in early diagnosis, especially if tissue is sparse.
Treatment of localized non-Hodgkin's lymphomas of the head and neck: focusing on cases of non-lethal midline granuloma.
Radiotherapy is excellent for obtaining local control of head and neck NHL and Randomized trials are required to determine the appropriate radiation field and dose in patients previously treated with chemotherapy.
Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy.
There was no difference in survival between RT and CRT in angiocentric T-cell and NK/T-cell lymphoma, nasal type.
Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification.
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