Lethal H5N1 influenza viruses escape host anti-viral cytokine responses

@article{Seo2002LethalHI,
  title={Lethal H5N1 influenza viruses escape host anti-viral cytokine responses},
  author={Sang Heui Seo and Erich Hoffmann and Robert G. Webster},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={950-954}
}
The H5N1 influenza viruses transmitted to humans in 1997 were highly virulent, but the mechanism of their virulence in humans is largely unknown. Here we show that lethal H5N1 influenza viruses, unlike other human, avian and swine influenza viruses, are resistant to the antiviral effects of interferons and tumor necrosis factor α. The nonstructural (NS) gene of H5N1 viruses is associated with this resistance. Pigs infected with recombinant human H1N1 influenza virus that carried the H5N1 NS… Expand
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